URIC ACID
Uric acid is a chemical produced by body as a result of breakdown of purines nucleotides. It is a normal component of urine. Formula of uric acid is C5H4N4O3.
The body produces purines, which are also found in some foods. Beer, dry beans and peas, liver, anchovies, and mackerel are foods high in purines. (003476 @ Medlineplus.Gov, n.d.)
Normal Concentration of Uric acid
In humans, the normal concentration of uric acid in men is 25-80mg/L and in women, 15-60mg/L. (Uric-Acid—-Blood- @ Www.Ucsfhealth.Org, n.d.)
Max. level of uric acid in serum can be 96mg/L.
HYPERURICEMIA
Hyperuricemia is defined as high level of uric acid in serums. Most uric acid is dissolved in blood, pass through kidney and leaves body in urine but if high amount of uric acid stays in body, it leads to hyperuricemia.
SYMPTOMS OF HYPERURICEMIA
Tophi Formation: Tophi, which are hard lumps of uric acid crystals under the skin, can develop as a result of chronic hyperuricemia, or increased uric acid levels. (Home-Remedies-for-High-Uric-Acid @ Www.Truemeds.In, n.d.)

Frequent urine: As the body tries to eliminate the extra acid, elevated uric acid levels might cause more frequent urine.
Gout:

- Gout includes the following symptoms:
- Joint stiffness
- Difficulty in moving joints
- Pain in joints that can worsen over period of 8-12 hours.
- Swelling in joints
- Kidney Stones:
- Foul smelling urine
- Painful urination
- Blood in urine
- Nausea
- Pain in lower back, abdomen
CAUSES OF HYPERURICEMIA
- Hyperuricemia can have many potential origins such as:
- Diet rich in Purines, sucrose can increase the level of uric acid.
- Red meat (organ meat like liver)
- Seafood
- Alcohol
- Less intake of water can concentrate uric acid in body.
- Rapid weight loss or fasting may cause uric acid levels to momentarily rise. (E68552451b6f7aec4b67d2f3b8eb1aa13325d1fc @ Pubmed.Ncbi.Nlm.Nih.Gov, n.d.)
- Some medicines such as Diuretics, Immunosuppressants etc.
- Overproduction of uric acid because of over metabolism of purines.
- Decreased uric acid excretion because of acute/chronic kidney disease, acidosis, hypothyroidism etc.
- Weight gain and Insulin Resistance
Consuming a lot of sugar can cause weight gain, and being overweight or obese is a risk factor for high uric acid. Insulin resistance, a condition in which your cells don’t respond to insulin properly, can lower the kidneys’ ability to excrete uric acid, raising its levels.
TREATMENT OF HYPERURICEMIA
Hyperuricemia can be treated at home and can be prevented by dietary Changes and maintaining healthy lifestyle.
Eat Less Purines
- Some foods are rich in purine and thus leads to more metabolism of purines to uric acid. Limiting purine- rich food can prevent hyperuricemia. (325317 @ Www.Medicalnewstoday.Com, n.d.)
- Foods with high purine are:
- Organ meats: Liver, kidneys, sweetbreads, brain, and heart.
- Red meats: Beef, pork, lamb, and veal.
- Game meats: Venison, rabbit, and wild birds.
- Processed meats: Sausages, bacon, and luncheon meats.
- Fish: Sardines, mackerel, anchovies, herring, trout, tuna, and haddock.
- Shellfish: Mussels, scallops, shrimp, lobster, and crab.
- Other seafood: Roe (fish eggs) and caviar.

Foods with less purine content are:

Drinking plenty of water
Kidneys flush out almost two-third of uric acid. Drinking more water helps kidney to remove uric acid faster.
Moreover, swelling and inflammation in joints can also be cured by excess removal of water through kidney.
Include Vitamin C
Consuming vitamin C-rich foods (like citrus fruits, strawberries, and bell peppers) may help lower uric acid.
Use of Green Tea
By boosting uric acid excretion and decreasing uric acid synthesis, the use of green tea polyphenols lowers the amount of uric acid in the blood. (S0378874115301124 @ Www.Sciencedirect.Com, n.d.)
Eat Dark chocolate
High cocoa content dark chocolate and less sugar has high antioxidant and anti-inflammatory properties. (Chocolate-and-Gout @ Www.Medicalnewstoday.Com, n.d.)
Flax seed / السی کے بیج
Use of flaxseed meal or flaxseed oil lowers the level of uric acid, plasma cholesterol and triglycerides concentrations in body. (S0955286302002279 @ Www.Sciencedirect.Com, n.d.)
Eating Cherries
Cherries can help reduce uric acid levels due to their anthocyanins, which are plant pigments that have anti-inflammatory and antioxidant properties. Cherries also contain vitamin C and quercetin, which may help lower uric acid. (How-to-Reduce-Uric-Acid @ Www.Healthline.Com, n.d.)

PREVENTION OF HYPERURICEMIA
Manage healthy body weight
The production of uric acid might be elevated by being overweight. With a healthy diet and consistent exercise, try to lose weight gradually.
Intake of balanced diet
Gout flare-ups can be prevented and uric acid levels lowered with a well-balanced diet rich in nutrient-dense, minimally processed foods. A plant-based, low-fat, low-carb diet may be very advantageous. A reliable source for gout sufferers. Antioxidants found in a variety of fruits and vegetables can aid in the reduction of inflammation.
Avoid Sugar
Because high uric acid levels are associated with oxidative stress and inflammation, refined sweets may exacerbate gout symptoms.
Coffee Intake
For the primary prevention of gout and hyperuricemia in both females and males a moderate coffee consumption is recommended. (S0049017216000299 @ Www.Sciencedirect.Com, n.d.)
Keep Yourself Calm and Control Your Stress
Excessive stress can raise your uric acid production and have an impact on your general health. Techniques like deep breathing, yoga, and meditation can be beneficial.
FREQUENTLY ASKED QUESTIONS
What is the best way to treat uric acid high levels at home?
Eating cherries can lessen gout flare-ups due to its anti-inflammatory qualities, and drinking lots of water aids in the body’s quick removal of uric acid.
what is the normal level of uric acid?
Regardless of age, normal uric acid levels typically fall between 2.5 and 7.0 mg/dL for men and 1.5 and 6.0 mg/dL for women.
What is the best tablet for the cure of hyperuricemia?
Allopurinol The recommended first-line treatment for hyperuricemia in people who overproduce uric acid is a xanthine oxidase inhibitor.
What is the alternative of Allopurinol?
Febuxostat is an allopurinol substitute that also effectively lowers uric acid levels.
What is the best tablet for the pain relief of gout flare ups?
NSAIDs, or non-steroidal anti-inflammatory medicines These prescription or over-the-counter medications help lessen swelling and pain. Ibuprofen (Advil, Motrin IB) and naproxen sodium (Aleve) are two examples.
KEY WORDS
High uric acid levels, Joint pain, Hyperuricemia, Home treatment for Hyperuricemia
REFERENCES
- 003476 @ medlineplus.gov. (n.d.). https://medlineplus.gov/ency/article/003476.htm
- 325317 @ www.medicalnewstoday.com. (n.d.). https://www.medicalnewstoday.com/articles/325317#limit-purine-rich-foods
- chocolate-and-gout @ www.medicalnewstoday.com. (n.d.). https://www.medicalnewstoday.com/articles/chocolate-and-gout#sugar-free-chocolate
- e68552451b6f7aec4b67d2f3b8eb1aa13325d1fc @ pubmed.ncbi.nlm.nih.gov. (n.d.). https://pubmed.ncbi.nlm.nih.gov/7024153/
- home-remedies-for-high-uric-acid @ www.truemeds.in. (n.d.). https://www.truemeds.in/blog/home-remedies-for-high-uric-acid
- how-to-reduce-uric-acid @ www.healthline.com. (n.d.). https://www.healthline.com/health/how-to-reduce-uric-acid#boost-vitamin-c
- S0049017216000299 @ www.sciencedirect.com. (n.d.). https://www.sciencedirect.com/science/article/abs/pii/S0049017216000299
- S0378874115301124 @ www.sciencedirect.com. (n.d.). https://www.sciencedirect.com/science/article/abs/pii/S0378874115301124#:~:text=Pages 14-20-,Green tea polyphenols decreases uric acid level through xanthine oxidase,urate transporters in hyperuricemic mice
- S0955286302002279 @ www.sciencedirect.com. (n.d.). https://www.sciencedirect.com/science/article/abs/pii/S0955286302002279
- uric-acid—-blood- @ www.ucsfhealth.org. (n.d.). https://www.ucsfhealth.org/medical-tests/uric-